A PDRN Skin Booster is an advanced medical aesthetic treatment designed to rejuvenate and revitalize the skin using PDRN (Polydeoxyribonucleotide), a compound derived primarily from salmon DNA. PDRN is renowned for its regenerative and healing properties, making it a popular choice in dermatology and cosmetic medicine for skin repair, anti-aging, and overall revitalization. 

How Does PDRN Work?

• Cellular Regeneration: PDRN stimulates the metabolic activity of skin cells, encouraging them to repair and regenerate.
• Collagen Production: It promotes the growth of fibroblasts—cells responsible for producing collagen and elastin—leading to improved skin elasticity and firmness.
• Tissue Healing: PDRN enhances wound healing, reduces the appearance of scars (including acne scars), and accelerates recovery after skin procedures.
• Hydration and Brightening: The treatment increases skin hydration and can improve overall skin tone and luminosity.
• Anti-Inflammatory and Antioxidant Effects: PDRN also exhibits anti-inflammatory properties, helping to calm irritated skin and protect against environmental damage.

Treatment Process

• Microinjections: PDRN Skin Boosters are typically administered through a series of microinjections directly into the dermis (the skin’s middle layer), ensuring the compound reaches the cells responsible for regeneration.

• Combination Formulas: Some PDRN boosters are combined with hyaluronic acid for enhanced hydration and skin plumping effects.

Benefits of PDRN Skin Boosters

• Reduces fine lines, wrinkles, and pore size

• Improves skin elasticity, firmness, and hydration

• Minimizes scars and stretch marks

• Evens out skin tone and brightens complexion

• Accelerates healing after cosmetic procedures

• Suitable for a wide range of skin types and ages, both as a preventive and corrective treatment.

Side Effects and Recovery

Side effects are typically mild and temporary, including small bumps, redness, or swelling at the injection sites, which usually subside within a few days. Post-treatment care includes gentle skincare and sun protection.

Popular PDRN Injectables Available in the Market (2025)

PDRN (Polydeoxyribonucleotide) injectables are highly sought-after for their regenerative, anti-aging, and healing effects in aesthetic medicine. Below is an overview of the most popular PDRN injectable brands and products currently available:

1. Rejuran (South Korea)

2. Diamond Shine (South Korea)

3. ElaSkin (South Korea)

4. Placentex (Italy)

PN (Polynucleotide) Injectables

While not strictly PDRN, PN boosters are closely related, offering higher DNA concentrations for more intensive anti-aging effects. PN (Polynucleotide) injectables are advanced skin boosters derived from salmon DNA, designed for comprehensive skin rejuvenation and long-term dermal support. They are increasingly popular in aesthetic medicine for their robust anti-aging and regenerative effects.

Key Features of PN Injectables

• High Molecular Weight, Long-Chain Structure: PN consists of longer DNA chains and a higher molecular weight (about 1000–1500K Daltons) compared to PDRN (350–750K Daltons). This structure allows PN to remain active in the skin longer, offering sustained stimulation of fibroblasts and prolonged collagen production. Ref 1

• Concentration: PN injectables contain a higher concentration of polynucleotides (typically 10–14mg/mL) than PDRN products (3–5mg/mL), resulting in more pronounced and longer-lasting anti-aging effects, especially for severe skin aging or laxity. Ref 2

• Mechanism of Action: PN works by activating fibroblasts, promoting collagen synthesis, improving elasticity, and enhancing overall skin texture. Its higher-order polymer structure also provides potent anti-inflammatory action, making it suitable for treating inflammatory skin conditions.

• Indications: PN is ideal for global (full-face) skin rejuvenation, long-term anti-aging, and sustained dermal support. It is particularly effective for patients seeking intensive treatment for deep wrinkles, skin laxity, or overall skin firmness and glow.

• Duration: The effects of PN last longer (about one month) compared to PDRN (about half a month), making it a preferred choice for those seeking longer intervals between treatments. Ref 1

Check the available PN injectables on our website

1. Rejuran: The most widely recognized PN injectable, approved by the KFDA and used for anti-aging and overall skin rejuvenation. JDBIO is an Official Sales Partner for Rejuran. 

2. Richesse Eyes: A JDBIO product that contains Hyaluronic Acid and 0.2% high quality PN it helps in rejuvenation of overall skin and brightens it. Mostly used for under eyes it can be used for full face too. 

Shop our products here : Website

While PDRN is getting increasingly popular Worldwide PN injectables and over the counter treatments are also slowly becoming popular and available in the market. Now that you are aware of the difference and their functions you can ask your medical aestheticians for its availability in the clinic and get that boost of glow, radiance, rejuvenation. If you are scared of injections you can also use JDBIO’s Richesse Eyes with MTS device at home without having to inject it. Try Now : JDBIOSHOP

Learn about other types of skin boosters here